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A member of Cambridge University Health Partners -

Dr Karen Sheares

Contact Details
Switchboard 01480 830541
Fax 01480 364267

Amanda Lawrenson, Grace Trimmer and Michaela Parr
Tel: 01480 364223 / 01480 364109 / 01480 364627

Respiratory Medicine
Pulmonary Vascular Diseases
Clinical Pharmacology and Therapeutics

Specialist Clinical Interests

Pulmonary Arterial Hypertension
Acute and Chronic Thromboembolic Disease
Chronic Thromboembolic Pulmonary Hypertension

Research Interests
Pulmonary Arterial Hypertension
Chronic Thromboembolic Pulmonary Hypertension

Professional Profile
Dr Karen Sheares obtained her BA (Hons) in Physiological Sciences in 1990 and continued at Oxford University Medical School graduating with the degree of BM BCh in 1993. She commenced postgraduate training and obtained her MA in 1995 and MRCP in 1996. Subsequently she started an innovative and unique specialist registrar training programme in Respiratory Medicine, Clinical Pharmacology and General Medicine in Addenbrooke’s Hospital and Papworth Hospital. During this time, she was awarded a British Heart Foundation research fellowship to investigate how low oxygen levels regulate the growth of pulmonary artery smooth muscle cells resulting in pulmonary hypertension. This culminated in a PhD from the University of Cambridge in 2005.
She was appointed as Respiratory Consultant at Papworth Hospital and Honorary Respiratory Consultant in Cambridge University Hospitals in 2006 and obtained FRCP in 2011. She is the Respiratory expert on the National Institute for Health and Care Excellence’s Venous Thromboembolic Diseases Guidelines and Quality Standards Groups. She is the Clinical Pharmacology representative on the Papworth Hospital Drugs and Therapeutics Committee. Her research interest is the pathogenesis of pulmonary vascular remodelling in pulmonary hypertension particularly in the thromboembolic group.

Education and Training
1990 BA (Hons) University of Oxford
1993 BM BCh University of Oxford
1995 MA University of Oxford
1996 MRCP London
2005 PhD University of Cambridge
2011 FRCP London

Current membership(s) of professional, national and regional bodies and university posts
General Medical Council
Fellow of the Royal College of Physicians
British Thoracic Society
International Chronic Thromboembolic Pulmonary Hypertension Association

Recent and Important Publications
Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JS, Howard LS, Pepke-Zaba J, Sheares KK, Corris PA, Fisher AJ, Lordan JL, Gaine S, Coghlan JG, Wort SJ, Gatzoulis MA, Peacock AJ. Am J Respir Crit Care Med. 2012 Oct 15;186(8):790-6.

Management of venous thromboembolic diseases and the role of thrombophilia testing: summary of NICE guidance. Chong LY, Fenu E, Stansby G, Hodgkinson S; Guideline Development Group. BMJ. 2012 Jun 27;344:

Pulmonary endarterectomy: outcomes in patients aged >70.Berman M, Hardman G, Sharples L, Pepke-Zaba J, Sheares K, Tsui S, Dunning J, Jenkins DP. Eur J Cardiothorac Surg. 2012 Jun;41(6):e154-60.

Predicting survival in pulmonary arterial hypertension in the UK. Lee WT, Ling Y, Sheares KK, Pepke-Zaba J, Peacock AJ, Johnson MK. Eur Respir J. 2012 Sep;40(3):604-11.

Occlusion pressure analysis role in partitioning of pulmonary vascular resistance in CTEPH. Toshner M, Suntharalingam J, Fesler P, Soon E, Sheares KK, Jenkins D, White P, Morrell NW, Naeije R, Pepke-Zaba J. Eur Respir J. 2012 Sep;40(3):612-7
Imaging in pulmonary hypertension, part 3: small vessel diseases. Gopalan D, McCann C, Sheares K, Screaton N. Postgrad Med J. 2012 Jul;88(1041):397-406

Imaging in pulmonary hypertension, part 2: Large vessel diseases.McCann C, Gopalan D, Sheares K, Screaton N. Postgrad Med J. 2012 Jun;88(1040):317-25.

Imaging in pulmonary hypertension, part 1: clinical perspectives, classification, imaging techniques and imaging algorithm. McCann C, Gopalan D, Sheares K, Screaton N. Postgrad Med J. 2012 May;88(1039):271-9

How do I manage a patient with suspected acute pulmonary embolism? Sheares KK. Clin Med. 2011 Apr;11(2):156-9.

Log-transformation improves the prognostic value of serial NT-proBNP levels in apparently stable pulmonary arterial hypertension. Soon E, Doughty NJ, Treacy CM, Ross RM, Toshner M, Upton PD, Sheares K, Morrell NW, Pepke-Zaba J. Pulm Circ. 2011 Apr-Jun;1(2):244-9

Risk of potentially life-threatening thyroid dysfunction due to amiodarone in idiopathic pulmonary arterial hypertension patients. Soon E, Toshner M, Mela M, Grace A, Sheares K, Morrell N, Pepke-Zaba J. J Am Coll Cardiol. 2011 Feb 22;57(8):997-8

Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension.Soon E, Treacy CM, Toshner MR, MacKenzie-Ross R, Manglam V, Busbridge M, Sinclair-McGarvie M, Arnold J, Sheares KK, Morrell NW, Pepke-Zaba J. Thorax. 2011 Apr;66(4):326-32

Survival after pulmonary thromboendarterectomy: Effect of residual pulmonary hypertension. Freed DH, Thomson BM, Berman M, Tsui SS, Dunning J, Sheares KK, Pepke-Zaba J, Jenkins DP. J Thorac Cardiovasc Surg. 2010 May 12. 

Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension. Toshner MR, Gopalan D, Suntharalingam J, Treacy C, Soon E, Sheares KK, Morrell NW, Screaton N, Pepke-Zaba J. J Heart Lung Transplant. 2010 Jun;29(6):610-5. 

Functional and haemodynamic outcome 1 year after pulmonary thromboendarterectomy.Freed DH, Thomson BM, Tsui SS, Dunning JJ, Sheares KK, Pepke-Zaba J, Jenkins DP. Eur J Cardiothorac Surg. 2008 Sep;34(3):525-9.
Improved outcomes in medically and surgically treated chronic thromboembolic pulmonary hypertension. Condliffe R, Kiely DG, Gibbs JS, Corris PA, Peacock AJ, Jenkins DP, Hodgkins D, Goldsmith K, Hughes RJ, Sheares K, Tsui SS, Armstrong IJ, Torpy C, Crackett R, Carlin CM, Das C, Coghlan JG, Pepke-Zaba J. Am J Respir Crit Care Med. 2008 May 15;177(10):1122-7.

Consensus statement on the management of pulmonary hypertension in clinical practice in UK and Ireland. National Pulmonary Hypertension Centres of UK and Ireland. Supplement   Heart 2008;94 Suppl I and Thorax 2008;63 Suppl II

Long-term use of sildenafil in inoperable chronic thromboembolic pulmonary hypertension. Suntharalingam J, Treacy CM, Doughty NJ, Goldsmith K, Soon E, Toshner MR, Sheares KK, Hughes R, Morrell NW, Pepke-Zaba J. Chest. 2008 Aug;134(2):229-36.

Role of NT-proBNP and 6MWD in chronic thromboembolic pulmonary hypertension.
Suntharalingam J, Goldsmith K, Toshner M, Doughty N, Sheares KK, Hughes R, Jenkins D, Pepke-Zaba J. Respir Med. 2007 Nov;101(11):2254-62.
Acute haemodynamic responses to inhaled nitric oxide and intravenous sildenafil in distal chronic thromboembolic pulmonary hypertension (CTEPH). Suntharalingam J, Hughes RJ, Goldsmith K, Doughty N, George P, Toshner M, Sheares KK, Pepke-Zaba J. Vascul Pharmacol. 2007 Jun;46(6):449-55.
Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension. Suntharalingam J, Machado RD, Sharples LD, Toshner MR, Sheares KK, Hughes RJ, Jenkins DP, Trembath RC, Morrell NW, Pepke-Zaba J. Thorax. 2007 Jul;62(7):617-22.


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