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Dr Stephen HooleDr Stephen Hoole

Consultant Cardiologist

Contact Details
Switchboard 01480 830541
Fax 01480 831315

Kayreen Waldron-Andrade
Tel 01480 364119

Cardiology, Interventional Cardiology

Specialist Clinical Interests
Coronary Intervention, chronic total occlusion PCI,  Structural Intervention, Interventional Research, CT coronary angiography, cardiac support devices and balloon pulmonary angioplasty for CTEPH

Research Interests
Coronary stent safety
Cardioprotection during PCI
Metabolic optimisation during PCI
Myocardial injury during revascularization
Coronary/left ventricular physiological assessment during PCI
Coronary microvascular and collateral function assessment during PCI
Vulnerable plaque imaging with VH-IVUS and OCT
Biomarker profiling during PCI
Coronary intervention risk prediction modeling
Coronary stent design & technology
Innovation of interventional devices
PFO closure in sleep apneoa
Right ventricular haemodynamics

Professional Profile
Dr Hoole qualified in medicine with distinction from Christ Church, University of Oxford, and subsequently trained in cardiology in Nottingham, London and Cambridge. He completed a doctorate in the Department of Cardiovascular Medicine, University of Cambridge, where he investigated cardioprotective strategies to improve PCI outcomes. He was shortlisted for the Thomas J. Linnemeier Spirit of Interventional Cardiology International Young Investigator Award for this work. He was awarded an NIHR Clinical Lectureship in cardiology by the University of Cambridge and completed his training with an interventional fellowship in Vancouver, Canada.

Dr Hoole was appointed as a consultant interventional cardiologist in January 2012 and leads interventional cardiology research in Cambridge.

He was accepted into the 2013-2015 Society of Cardiovascular Angiography and Interventions Emerging Leader Mentorship (SCAI-ELM) program as one of 12 national and international SCAI-ELM fellows.

Education and Training
1995   BA (Class: I), University of Oxford
1998   BM BCh, University of Oxford
2001   MRCP, London
2001   MA, University of Oxford
2009   DM, University of Oxford
2010   Board Certified CCT, USA
2015   FESC
2015   FACC    
2016   FRCP, London

Current membership(s) of professional, national and regional bodies and university posts
Fellow of the Royal College of Physicians, London
Fellow of the American College of Cardiology
Fellow of the European Society of Cardiology
British Cardiovascular Intervention Society
General Medical Council (Full registration: 4530426)
Specialist Advisor to National Institute for Health and Clinical Excellence
Specialist Advisor to NIHR HTA Programme
Specialist Adviser to MHRA Interventional Devices Programme
Member of NICE NCGC Acute Chest Pain Guideline Committee, RCP
Member of Regional Specialist Training Committee (Cardiology), Eastern Deanery

Clinical Outcomes
To view Dr Hoole's clinical outcomes, please click on this link. This will take you to the British Cardiovascular Intervention Society website which is not part of the Papworth Hospital website.

Recent and Important Publications
Selected Journal Publications:

Brown AJ, Teng Z, Calvert PA, Rajani NK, Hennessy O, Obaid DR, Costopoulos C, Huang Y, Hoole SP, Goddard M, West NEJ, Gillard JH, Bennett MR Plaque structural stress estimations improve prediction of future major adverse cardiovascular events following intracoronary imaging. Circ Cardiovasc Imaging 2016 in press
Giblett JP, SJ Clarke, DP Dutka, Hoole SP  Glucagon-like Peptide-1: a promising agent for cardioprotection during myocardial ischemia. JACC Basic Translational Science 2016 in press
Giblett JP, Brown AJ, Keevil H, Jaworski C, Hoole SP, West NEJ Implantation of Bioresorbable Vascular Scaffolds following Acute Coronary Syndrome is Associated with Reduced Neointimal Growth and Strut Coverage. Eurointervention 2016 in press
Hoole SP, Clarke SC Navigating optimal revascularisation for unprotected left main disease in changing interventional seas. JACC Cardiovasc Interv 2016 9(10):1008-10
Hoole SP, West NEJ What is the place of bivalirudin in contemporary invasive treatment of acute coronary syndromes? BMJ 2016 352:i86
Brown AJ, Calvert PA, Hoole SP, Obaid DR, West NEJ, Bennett MR Geographical miss is associated with vulnerable plaque and increased major adverse cardiovascular events in patients with myocardial infarction. CCI 2015 doi: 10.1002/ccd.26275.
Brown AJ, Costopoulos C, Obaid D, Parker R, Calvert PA, Teng Z, Hoole SP, Goddard M, West NEJ, Bennett MR. Direct comparison of virtual-histology intravascular ultrasound and optical coherence tomography imaging for identification of thin-cap fibroatheroma. Circ Cardiovasc Imaging 2015 ;8:e003487. DOI: 10.1161/CIRCIMAGING.115.003487
Costopoulos C, Brown AJ, Hoole SP, West NE Mid-term clinical outcomes of ABSORB bioresorbable vascular scaffold implantation in a real-world population: a single-center experience. Cardiovasc Revasc Medicine 2015, 16(8):461-4.

McCormick LM, Heck PM, Ring LS, Kydd AC, Clarke SJ, Hoole SP, Dutka DP Glucagon-like peptide-1 protects against ischemic left ventricular dysfunction during hyperglycemia in patients with coronary artery disease and type 2 diabetes mellitus. Cardiovasc Diabet 2015 14:102 doi:10.1186/s12933-015-0259-3

Costopoulos C, Brown AJ, Teng Z, Hoole SP, West NE, Samady H, Bennett MR Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis. Int J Cardiovasc Imaging 2015, 32(1):189-200

Abah U, Dunne M, Cook A, Hoole SP, Brayne C, Vale L, Large S Does Quality of Life improve in Octogenarians following Cardiac Surgery? A Systematic Review. BMJ Open 2015 5(4):e006904. doi: 10.1136/bmjopen-2014-006904

Brown AJ, Hoole SP, West NEJ Optical Coherence Tomography Imaging of Coronary Atherosclerosis is Affected by Intra and Inter-observer Variability. J Cardiovasc Med 2015 17(5):368-73

Hoole SP, Brown AJ, Jaworski C, McCormick LM, Clarke SC, West NEJ Interpretation of Fractional Flow Reserve in ST-Elevation Myocardial Infarction Culprit Lesions. Coron Artery Dis 2015 26(6): 495-502

Ranjani NK, Brown AJ, Hoole SP, West NEJ Switching from Transfemoral to Transradial Access for Percutaneous Coronary Intervention – Do The Benefits Perceived in RCTs Translate to Routine Practice. J Interv Card 2015  28 (3), 296-304, 2015

Hoole SP, Jaworski C, Brown AJ, McCormick LM, Agrawal B, Clarke SC, West NEJ Serial Assessment of the Index of Microcirculatory Resistance during Primary Percutaneous Coronary Intervention comparing Manual Aspiration Catheter Thrombectomy with Balloon Angioplasty (IMPACT study) - a Randomised Controlled Pilot Study. OpenHeart 2015 2 (1), e000238, 2015

Giblett JP, West NEJ, Hoole SP. Cardioprotection for Percutaneous Coronary Intervention – Reperfusion Quality as well as Quantity. Int J Cardiol. 2014, 177(3): 786-793

McCormick LM, Hoole SP, White PA, Read PA, Axell RG, Clarke SJ, O’Sullivan M, West NEJ, Dutka DP Pre-treatment with glucagon-like Peptide-1 protects against ischemic left ventricular dysfunction and stunning without a detected difference in myocardial substrate utilization. JACC Cardiovasc Interv 2015: 8(2): 292-301

McCormick LM, Brown AJ, Ring LS, Gajendragadkar PR, Dockrill SJ, Hansom SP, Giblett JP, Gilbert TJ, Hoole SP, West NE Direct stenting is an independent predictor of improved survival in patients undergoing primary PCI for STEMI. EHJ ACC 2014 3(4):340-6

Brown AJ, McCormick LM, Braganza DM, Bennett MR, Hoole SP, West NEJ Expansion and malapposition characteristics after OCT guided bioresorbable vascular scaffold implantation Catheter Cardiovasc Interv 2014, 84(1):37-45

McCabe C, White PA, Rana BS, Gopalan D , Agrawal B, Pepke-Zaba J, Hoole SP RV functional assessment: have new techniques supplanted the old faithful conductance catheter? Cardio in Review 2014, 22(5):233-40.

McCormick LM, Kydd AC, Read PR, Ring LS, Hoole SP, Dutka DP Chronic DPP-4 Inhibition with Sitigliptin Is Associated with Sustained Protection Against Ischemic LV Dysfunction in Patients with Type 2 Diabetes Mellitus and Coronary Artery Disease Circ Imaging 2014 7(2):274-81

Teng Z, Brown AJ, Calvert PA, Parker RA, Obaid DR, Huang Y, Hoole SP, West NEJ, Gillard JH, Bennett MR Coronary plaque structural stress is determined by plaque composition and subtype and increased in acute coronary syndrome: the BEACON I (Biomechanical Evaluation of Atheromatous COroNary Arteries) Study Circ Imaging 2014 7(3):461-70

McCabe C, White PA, Hoole SP, Axell R, Priest A, Gopalan D, Taboada D, MacKenzie-Ross R, Morrell N, Shapiro LM, Pepke-Zaba J Right Ventricular Dysfunction in Chronic Thromboembolic Obstruction of the Pulmonary Artery. J Appl Physiol 2014, 116(4):355-63

Brown AJ, McCormick LM, Gajendragadkar PR, Hoole SP, West NEJ. Initial SYNTAX score predicts major adverse cardiac events after primary percutaneous coronary intervention. Angiology 2014, 65(5):408-12.

Obaid DR, Calvert PA, Gopalan D, Hoole SP, West NEJ, Goddard M, Rudd JHF, Bennett MR. Atherosclerotic plaque composition and classification identified by coronary CT: Assessment of CT- generated plaque maps compared with VH-IVUS and histology Circ Cardiovasc Imaging 2013 6(5):655-64

Davies WR, Brown AJ, Watson W, McCormick LM, West NEJ, Dutka DP, Hoole SP. Remote Ischemic Pre-conditioning Improves Outcome at Six Years Following Elective Percutaneous Coronary Intervention: The CRISP-Stent Trial Long Term Follow-Up. Circ Intervention 2013, 6(3):246-51

Brown AJ, Hoole SP, McCormick LM, Malone-Lee M, Cacciottolo PJ, Schofield PM, West NEJ. Left bundle branch block with acute thrombotic occlusion is associated with increased myocardial jeopardy score and poor clinical outcomes in primary percutaneous coronary intervention activations. Heart 2013, 99(11):774-8.

Rekhraj S, McNab DC, Shapiro LM, Hoole SP, Rana BS Hypoxia in a patient with carcinoid syndrome J Am Coll Cardiol 2013, 62(17): e241

Brown AJ, McCormick LM, Hoole SP, West NEJ. Co-registered intravascular ultrasound and optical J Am Coll Cardiol 2013coherence tomography imaging during implantation of a bioresorbable vascular scaffold. JACC Cardiovasc Interv 2013, 6(7): e41-42

Hoole SP, Rana B, Shapiro LM, Davies M. No closure for patent foramen ovale in obstructive sleep apnea? Chest 2013;143(2):581-2

Vassiliou V, West NEJ, Hoole SP. Kounis syndrome: not to be sneezed at. Heart 2013;99(1):68.

McCormick LM, Hoole SP, Brown AJ, Dutka DP, West NE. A contemporary re-evaluation of culprit lesion severity in patients presenting with STEMI. Acute Card Care. 2012;14(4):111-6.

Hoole SP
, White PA, Read PA, Heck PM, West NE, O’Sullivan M, Dutka DP. Coronary Collaterals Provide a Constant Scaffold Effect on the Left Ventricle and Limit Ischemic Left Ventricular Dysfunction in Humans. J Appl Physiol. 2012;112(8):1403-9.

Hoole SP, Seddon MD, Poulter RS, Mancini GBJ, Wood DA, Saw J.Development and Validation of the FFR Angiographic Scoring Tool (FAST) to Improve the Angiographic Grading and Selection of Intermediate Lesions that Require FFR Assessment. Coron Artery Dis 2012, 23(1): 45-50

Read PA, Hoole SP, White PA, Khan FZ, O’Sullivan M, West NEJ, Dutka DP. A Pilot Study to Assess Whether Glucagon-like peptide-1 protects the Heart from Ischemic Dysfunction and Attenuates Stunning Following Coronary Balloon Occlusion in Humans. Circ Intervention 2011, 4(3): 266-72

Hoole SP, Seddon MD, Poulter RS, Mancini GBJ, Wood DA, Saw J. FAME comes at a cost – a Canadian Analysis of Procedural Costs in Using Pressure Wire to Guide Multivessel PCI. Can J Cardiol. 2011, 27 (2): 262

Hoole SP, Hamburger JN. Comparing Procedural Risks to Select the Optimal Revascularization Strategy –Certainty in an Uncertain Anatomical World. Catheter Cardiovasc Interv 2011, 77 (2): 313-314

Hoole SP, Heck PM, Epstein AC, Clarke SC, West NE, Dutka DP. Elective Coronary Stenting Increases Fractional Flow Reserve in other arteries due to an increase in Microvascular Resistance: Clinical Implications for Assessment of Multi-vessel disease. J Interv Card 2010, 23(6):520-7.

Hoole SP, Heck PM, Sharples L, Dutka DP West NEJ. Coronary stent length predicts PCI-induced cardiac myonecrosis. Coron Artery Dis 2010, 21(5): 312-7

Heck PM, Hoole SP, Khan SN, Dutka DP. Hyperinsulinemia improves ischemic LV function in insulin resistant subjects. 
Cardiovasc Diabetol 2010, 9:27

Hoole SP, Heck PM, White PA, Read PA, Khan SN, West NEJ, O’Sullivan M, Dutka DP. Stunning and Cumulative LV Dysfunction Occurs Late after Coronary Balloon Occlusion in Humans: Insights from Simultaneous Coronary and LV Hemodynamic Assessment. JACC Cardiovasc Interv 2010, 3(4): 412-8

West NEJ, Hoole SP, McCormick LAre All Distal Protection Devices Created Equal? J Am Coll Cardiol 2010, 56(9):745-6

Read PA, Khan FZ, Heck PM, Hoole SP, Dutka DP.DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. Circ Cardiovasc Imaging 2010, 3(2): 195-201

Hoole SP, Heck PM, Sharples L, Khan SN, Duehmke R, Densem CG, Clarke SC, Shapiro LM, Schofield PM, O’Sullivan M, Dutka DP. Cardiac Remote ISchemic Preconditioning in Coronary Stenting (CRISP stent) Study: a prospective, randomized controlled trial.  Circulation 2009, 119: 820-827

Hoole SP, Khan SN, White PA, Heck PM, Kharbanda RK, Densem CG, Clarke SC, Shapiro LM, Schofield PM, O’Sullivan M, Dutka DP. Remote Ischaemic Preconditioning Does Not Attenuate Ischaemic Left Ventricular Dysfunction in Humans. Eur J Heart Failure 2009, 11: 497-505

Hoole SP, White PA, Heck PM, Khan SN, Densem CG, Clarke SC, Shapiro LM, Schofield PM, O’Sullivan M, Dutka DP. Primary Coronary Microvascular Dysfunction and Poor Coronary Collaterals Predict Post-PCI Cardiac Necrosis. 
Coron Artery Dis 2009, 20 (4):253-259

Hoole SP, Heck PM, White PA, Khan SN, O’Sullivan M, Clarke SC, Dutka DP. Angiology 2009, 60 (4):403-11. Remote Ischemic Preconditioning Stimulus Does Not Reduce Microvascular Resistance or Improve Myocardial Blood Flow in Patients Undergoing Elective Percutaneous Coronary Intervention.


Coronary Angiography, Core Topics in Cardiothoracic Critical Care. Krishnan U, Hoole SP. Editors: Valchanov K, Jones N, Hogue C. Cambridge University Press 2016 in press

Cases for PACES 3e. Hoole SP, Fry A, Davies RJ. ISBN-10 1-1189-8357-2 Wiley Blackwell Publishing Group, 2015

Cases for PACES 2e. Hoole SP, Hodson DJ, Fry A, Davies RJ. ISBN 1-4051-9948-2 Wiley Blackwell Publishing Group, 2010

Cases for PACES. Hoole SP, Hodson DJ and Fry A.  ISBN 1-4051-1093-7 Blackwell Publishing Ltd, 2003


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