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Mr Ayyaz AliMr Ayyaz Ali

Consultant Surgeon

Contact Details
Switchboard 01480 830541
Fax 01480 831315

Cardiothoracic surgery
Cardiopulmonary transplantation

Specialist Clinical Interests
Coronary artery surgery
Aortic valve replacement
Cardiac transplantation
Lung transplantation
Mechanical circulatory support

Research Interests
Cardiac transplantation using DCD donors
Extracorporeal membrane oxygenation
Changes in circulatory physiology during ventricular assist device support
Aortic valve disease
Clinical outcomes following cardiac transplantation

Professional Profile
Ayyaz Ali received his medical degree from the University of Leicester. He trained in cardiothoracic surgery at Papworth Hospital in Cambridge, UK. He received further training in heart transplantation, lung transplantation and mechanical circulatory support devices for heart failure at two of the world’s largest thoracic transplant centers, the University of Pittsburgh Medical Center (Pittsburgh, Pennsylvania, U.S.A) and Duke University Medical Center (Durham, North Carolina, U.S.A.).  In addition to cardiac and transplant surgery, he has a strong background in both clinical and basic science research. He undertook research into the feasibility of heart transplantation from donors who suffer circulatory arrest at Stanford University in California. This work has been published in important medical journals and presented at numerous international meetings.  Mr. Ali holds an appointment as an associate research scientist at Columbia University Medical Center in New York, U.S.A, where he is actively researching mechanisms of recovery in the injured heart and lung with the use of artificial circulatory support devices.

Education and Training
MB ChB, University of Leicester
Membership of the Royal College of Surgeons of England
PhD, University of Leicester
Fellowship of the Royal College of Surgeons, Cardiothoracic Surgery (FRCS-CTh)

Current membership(s) of professional, national and regional bodies and university posts
General Medical Council
Fellow of the Royal College of Surgeons
Member of the International Society of Heart and Lung Transplantation

Recent and Important Publications 
Knight AJ, Ali AA, White SA, Nicholson ML, Dual renal allografts from a non-heart beating donor.  Transplant Int. 1999;12(6):466-7

Lim E, Ali Z, Ali A, Motalleb-Zadeh R, Jackson C, Ong SL, Halstead J, Sharples L, Parameshwar J, Wallwork J, Large SR.  Comparison of survival by allocation to medical therapy, surgery, or heart transplantation for ischemic advanced heart failure. J Heart Lung Transplant. 2005 Aug;24(8):983-9

Ali A, Halstead JC, Cafferty F, Sharples L, Rose F, Coulden R, Lee E, Dunning J, Argano V, Tsui S.  Are stentless valves superior to modern stented valves?  A prospective randomized trial.  Circulation. 2006 Jul 4;114(1 Suppl):I535-40.

Ali AA, Thanikachalam M, Lim E, Feccia M, Sudarshan C, Parameshwar J, White P, Large SR.  Cardiac arrest in the organ donor does not negatively influence recipient survival after heart transplantation.  Eur J Cardiothorac Surg.  2007 May;31 (5):929-33. 

Ali AA, Dhital K, White P, Ryan M., Tsui S, Large SR.  Cardiac recovery in a human non-heart-beating donor after extracorporeal perfusion : source for human heart donation? J Heart Lung Transplant 2009 Mar; 28(3):290-3.  

Lin HY, Freed D, Lee TW, Arora RC, Ali A, Almoustadi W, Xiang B, Wang F, Large s, King SB, Tomanek B, Tian G. Quantitative assessment of cardiac output and left ventricular function by noninvasive phase-contrast and cine MRI: Validation study with invasive pressure-volume loop analysis in a swine model.  J Magn Reson Imaging. 2011 May 19 [Epub]

Ali AA, Arora R, White P, Tian GH, Ashley E, Xiang B, Large S, Freed D.  Hearts from DCD donors display acceptable biventricular function after heart transplantation in pigs. Am J Transplant. 2011 Aug; 11(8):1621-32

Colah S, Freed DH, Mundt P, Germscheid S, White P, Ali A, Tian G, Large S, Falter F.  Ex vivo perfusion of the swine heart as a method of pre-transplant assessment.  Perfusion. 2012 June (published online)

Southerland KW, Castleberry AW, Williams JB, Daneshmand MA, Ali AA, Milano CA.  Impact of donor cardiac arrest on heart transplantation.  Surgery. 2013;154(2):312-9

White C, Ali AA, Hasanally D, Xiang B, Li Y, Mundt P, Lytwyn M, Colah S, Ravandi A, Arora RC, Lee TW, Hryshko L, Dhalla NS, Large S, Tian G, Freed DH.  A Cardioprotective preservation strategy employing ex vivo heart perFusion facilitates successful transplant of donor hearts after cardiocirculatory death. J Heart Lung Transplant. 2013;32(7):734-43

Ali AA, White CW, Freed DH, Ali Z, Large S.  Ethicality of heart transplantation from donation after circulatory death donors.  J Clin Exp Cardiolog. 2013, S9-006

Ali AA, Hartwig M, Lin S, Davis RD.  Bridge to Lung Transplant: What method and for Whom? Curr Respir Care Rep. 2013;2:173-179

Ali AA, Freed DH, Large S.  The Donation after Circulatory Death Donor can be a Source of Organs for Cardiac Transplantation. J Clin Exp Cardiolog. 2013; S9-007

Ali AA, Downey P, Singh G, Wei Q, George I, Takayama H, Kirtane A, Krishnan P, Freed DH, Large SR, Ashley EA, Leon M, Bacchetta M, Ali ZA.  Rat Model of Veno-Arterial Extracorporeal Membrane Oxygenation.  J Transl Med. 2014;12:37



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